Here I am discussing the histopathology of cervical cancer.
This is the area of the cervix that is visible to the physician’s eye when he does a speculum examination and normally this is covered with cells called “squamous cells”. At times the lining of the cervical canal, which has adenoid glands, grows a bit out of the canal onto the outside surface of the cervix. Second, when this tissue turns cancerous, the pathologist diagnoses “adenocarcinoma“, which happens in about 12% of all cervical cancer cases.
Poorly differentiated cervical cancer
Third, the remaining 3% of cervical cancer is diagnosed by the pathologist as “adenosquamous cell carcinoma“. As the name says, they are a mixture of both malignant adenocarcinoma and malignant squamous cell carcinoma. These cancers are what the pathologist calls “poorly differentiated carcinoma“, meaning that they are fast growing tumors with a cancer survival rate that is very poor.
To complicate the picture, there are three grading types of squamous cell carcinoma: a well-differentiated, a moderately differentiated and a poorly differentiated one . Each of them has a different grade of malignancy with the most mature cell type having the best longterm survival and the most immature (poorly differentiated) type having the worst survival.
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