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Basal Cell Carcinoma

Basal cell carcinoma is the most common skin cancer in white people in the U.S. and accounts for 77% of all non-melanoma skin cancers.

About 700,000 new cases are diagnosed and treated each year in the U.S. (Ref.6). It grows in skin that has been pre damaged by exposure to ultraviolet light. It rarely metastasizes like other cancers do, but it invades underlying surfaces including bone. It used to be a skin cancer of the older generation.

However, because of the obsession of suntanning from teenage years on it is not unusual to see patients in their 30’s or 40’s with the first basal cell tumor. The person that has developed one basal cell cancer, has a higher likelihood of developing more later in life. By the time a person has had 10 basal cell cancers, there is a probability that this person will develop one more such cancer in each following year.

Basal Cell Carcinoma

Basal Cell Carcinoma

The clinical appearance of the basal cell cancer is a skin colored to pink, shiny, raised papule which is slightly translucent and slowly growing. It may ulcerate in the center as it enlarges and develop a rolled border. There are various variations, which would be very familiar to the dermatologist to whom this patient should be referred to.

Treatment of basal cell cancer

Basal cell cancer can be treated by various means such as chemotherapy with topical 5-FU , radiotherapy or cryosurgery, which has a cure rate of 90% to 95%. However, a surgical technique called

Mohs’ micrographic surgery has a success rate of 96% to 99% (Ref. 4). This technique consists of a combination of microscopic shavings and analyses of the removed layers as frozen sections by the pathologist. With this method the dermatological surgeon can remove the last cells of the tumor under “microscopic” vision. This way not too much and not too little tissue is removed, which eliminates the danger of cancer recurrence almost completely.

 

References:

1. Kripke ML, Sass ER,eds.”Antigenicity of murine skin tumors induced by UV light”.JNCI 1974;53:1333-1336.

2. Kripke ML. “Immunology and photocarcinogenenis”. J. Am. Acad.Dermatol. 1986;14:149-155.

3. Potter M.”Percivall Pott’s contribution to cancer research”. NCI Monogr.1963;10:1.

4. COMS Group: Collaborative ocular melanoma study manual of procedures. National Technical Information Service. Springfield,VA, 1989.

5. Cancer: Principles &Practice of Oncology. 4th edition. Edited by Vincent T. DeVita, Jr. et al. Lippincott, Philadelphia,PA, 1993. Chapter on Cancer of the skin.

6. Cancer: Principles&Practice of Oncology. 5th edition, volume 2. Edited by Vincent T. DeVita, Jr. et al. Lippincott-Raven Publ., Philadelphia,PA, 1997. Chapter on Cancer of the skin.

7. Conn’s Current Therapy 2004, 56th ed., Copyright © 2004 Elsevier

8. Ferri: Ferri’s Clinical Advisor: Instant Diagnosis and Treatment, 2004 ed., Copyright © 2004 Mosby, Inc

9. Suzanne Somers: “Breakthrough” Eight Steps to Wellness– Life-altering Secrets from Today’s Cutting-edge Doctors”, Crown Publishers, 2008

Last modified: October 21, 2014

Disclaimer
This outline is only a teaching aid to patients and should stimulate you to ask the right questions when seeing your doctor. However, the responsibility of treatment stays in the hands of your doctor and you.