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Hypertension And High Risk Pregnancy

Hypertension and high risk pregnancy are connected: High blood pressure in a pregnant woman leads to blood vessel damage of the placenta, the heart and the kidney. The changes in these vital organs lead to an accelerated form to eclampsia with seizures, strokes, shock and kidney failure. Fortunately, this full picture of eclampsia is rare as the physician constantly checks for pre-eclampsia, the earliest form of pregnancy induced hypertension. We still do not know the exact pathophysiology of pre-eclampsia, but we do know that there is a typical symptom combination of hypertension, fluid retention, edema as well as leakage of protein from the kidneys (Ref. 18, p.935).

The three key signs of pre-eclampsia

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Hypertension, edema and protein leakage through the kidneys into the urine make up the classical three symptoms of pre-eclampsia. About 12% of primigravidas and 6% of multigravidas develop this syndrome, in twin pregnancies this rate is even higher. Pre-existing kidney disease or hypertension make the pregnant woman more susceptible to developing pre-eclampsia earlier in the pregnancy.

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Often,when pre-ecplampsia develops, bedrest is the first line of defence, sometimes reinforced in the hospital setting. If this does not lead to a satisfactory resolution, magnesium sulfate by intravenous drip is utilizied. A specialist (obstetrician) should be consulted for the more serious cases. There is some indication that oral calcium (1 or 2 Rolaids per day) will prevent minor pre-eclampsia cases (Ref.18, p. 943).

 

References

1. The Merck Manual: High risk pregnancy (thanks to www.merckmanuals.com for this link).

2. B. Sears: “Zone perfect meals in minutes”. Regan Books, Harper  Collins, 1997.

3. Ryan: Kistner’s Gynecology & Women’s Health, 7th ed.,1999 Mosby,  Inc.

4. The Merck Manual, 7th edition, by M. H. Beers et al., Whitehouse  Station, N.J., 1999. Chapter 245.

5. AB Diekman et al. Am J Reprod Immunol 2000 Mar; 43(3): 134-143.

6. V Damianova et al. Akush Ginekol (Sofia) 1999; 38(2): 31-33.

7. Townsend: Sabiston Textbook of Surgery,16th ed.,2001, W. B.  Saunders Company

8. Cotran: Robbins Pathologic Basis of Disease, 6th ed., 1999 W. B.  Saunders Company

9. Rakel: Conn’s Current Therapy 2001, 53rd ed., W. B. Saunders Co.

10. Ruddy: Kelley’s Textbook of Rheumatology, 6th ed.,2001 W. B.  Saunders Company

11. EC Janowsky et al. N Engl J Med Mar-2000; 342(11): 781-790.

12. Wilson: Williams Textbook of Endocrinology, 9th ed.,1998 W. B.  Saunders Company

13. KS Pena et al. Am Fam Physician 2001; 63(9): 1763-1770.

14. LM Apantaku Am Fam Physician Aug 2000; 62(3): 596-602.

15. Noble: Textbook of Primary Care Medicine, 3rd ed., 2001 Mosby,  Inc.

16. Goroll: Primary Care Medicine, 4th ed.,2000 Lippincott Williams &  Wilkins

17. St. Paul’s Hosp. Contin. Educ. Conf. Nov. 2001,Vancouver/BC

18. Gabbe: Obstetrics – Normal and Problem Pregnancies, 3rd ed.,  1996 Churchill Livingstone, Inc.

19. The Merck Manual, 7th edition, by M. H. Beers et al., Whitehouse  Station, N.J., 1999. Chapter 251.

20. The Merck Manual, 7th edition, by M. H. Beers et al., Whitehouse  Station, N.J., 1999. Chapter 250.

21. Ignaz P Semmelweiss: “Die Aetiologie, der Begriff und die  Prophylaxis des Kindbettfiebers” (“Etiology, the Understanding and  Prophylaxis of Childbed Fever”). Vienna (Austria), 1861.

22. Rosen: Emergency Medicine: Concepts and Clinical Practice, 4th  ed., 1998 Mosby-Year Book, Inc.

23. Mandell: Principles and Practice of Infectious Diseases, 5th ed.,  2000 Churchill Livingstone, Inc.

24. Horner NK et al. J Am Diet Assoc Nov-2000; 100(11): 1368-1380.

25. Ferri: Ferri’s Clinical Advisor: Instant Diagnosis and Treatment, 2004 ed., Copyright © 2004 Mosby, Inc.

26. Rakel: Conn’s Current Therapy 2004, 56th ed., Copyright © 2004 Elsevier

Last modified: November 12, 2014

Disclaimer
This outline is only a teaching aid to patients and should stimulate you to ask the right questions when seeing your doctor. However, the responsibility of treatment stays in the hands of your doctor and you.