In August 2014 the journal “Osteoporosis International” published a report from a trial where two groups of patients were compared, those who consumed high doses of vitamin E and those who only had low doses of vitamin E in their food intake; the hip fracture risks of both groups were compared after 11 years. Those whose vitamin E blood levels were lowest had a 51% higher risk of suffering a hip fracture when compared to the high vitamin E blood level group.
The data is based on community-based Norwegian studies that were conducted between 1994 and 2001. The experimental group consisted of 1168 subjects between the ages of 65 and 79 who had suffered hip fractures during up to 11 years of follow-up; blood samples for vitamin E levels (alpha-tocopherol) were obtained. They were compared to a control group from the same cohort, but consisted of subjects who did not suffer hip fractures during the observation period. Their vitamin E levels (alpha-tocopherol) were also taken.
The researchers noted that patients with the lowest 25% of vitamin E had a hip fracture risk that was 51% higher than the subjects with the highest levels of vitamin E. In other words the higher a person’s vitamin E level was the lower the hip fracture risk was. The researchers adjusted for body mass index, for serum vitamin D levels and other factors. It did not change the results.
The authors of the study suggested that oxidative stress contributes to osteoporosis. This is what leads to subsequent hip fractures. Vitamin E is a strong antioxidant, so it is not unexpected to find that vitamin E deficiency is a contributor to osteoporosis.
Comment: As the links below suggest, osteoporosis is a multifactorial condition where contributors are low vitamin D3 intake, low vitamin K2 intake, calcitonin deficiency and magnesium deficiency. Now it is also known that deficiency in vitamin E can also be a contributor to osteoporosis that leads to subsequent hip fractures.
More info on causes of osteoporosis:
1. General overview of osteoporosis causes: https://nethealthbook.com/arthritis/osteoporosis/causes-osteoporosis/
2. vitamin D3 and K2 required to prevent osteoporosis: http://www.askdrray.com/calcium-vitamin-d3-and-vitamin-k2-needed-for-bone-health/
Reference: Osteoporosis Int. 2014, Aug. 4