For years it was said that glucosamine would not work against arthritis. But people knew that when they combined glucosamine with chondroitin it was effective against arthritis. What is even more astounding is that it reduced the incidence of colorectal and lung cancers, a fact that the researchers from the Fred Hutchinson Cancer Research Center, Seattle, WA 98109 knew.
They devised an elaborate double-blind, crossover study to investigate the mechanism behind the beneficial effect of glucosamine/chondroitin on 18 overweight men and women between 20 and 55 years of age.
The first phase was a 28-day cycle of receiving 1200 mg of chondroitin sulfate and 1500 mg of glucosamine chloride per day or a placebo.
Next there was a washout period during which no supplements were given. This was followed by a 28-day cycle where treatments were switched: the previous placebo group got the supplements now, while the previous supplement group got placebos.
Blood samples were collected in the beginning of the trial before any supplements were given, then after each 28-day period. The main inflammatory marker that was determined was the C-reactive protein (CRP), but other inflammatory markers were also tested.
Symptoms of arthritis were improved in the glucosamine/chondroitin supplement group, but persisted in the placebo group. CRP levels were 23% lower at the end of the 28-day cycle with the glucosamine/chondroitin supplement group, but not in the placebo group. The researchers found that the “cytokine activity” pathway was inhibited by the glucosamine/chondroitin supplement and they believe that this is also the explanation, why lung and colorectal cancer are diminished when glucosamine/chondroitin supplements are taken.
Another study in the past had shown that a group of rheumatoid arthritis patients was able to reduce their anti-inflammatory medication by more than 30% when compared to a placebo group. They were supplemented with 2.2 grams of omega-3 fatty acids.
Omega-3 fatty acids are anti-inflammatory similar to glucosamine/chondroitin supplements.
We now know that inflammation is the reason for arthritis, but it is also present with the development of various cancers. Rather than wait until we get into trouble, it is far better to concentrate on prevention, eat an anti-inflammatory diet like the Mediterranean diet, and take supplements like omega-3 fatty acids and krill oil. Your body will thank you for it with good health.
More info on osteoarthritis: https://nethealthbook.com/arthritis/osteoarthritis/
More info on treatment of rheumatoid arthritis: https://nethealthbook.com/arthritis/rheumatoid-arthritis/treatment-rheumatoid-arthritis/