Here is a dementia overview. Dementia can be caused by many underlying conditions, from trauma (perhaps best known from boxing or multiple head injuries with hockey), but also from genetic causes like in Huntington’s disease or Lewy body dementia.
With the latter there is a strong association with Parkinson’s disease (genetic tests reveal PARK11 gene abnormalities).
However, dementia is only a unifying presentation of lack of function of the brain with abstract reasoning missing (cognitive decline), reasoning and planning is also absent. This makes functioning with regard to daily activities impossible and patients with dementia invariably end up in a special care home.
There is an age related component: only 3% of people aged 65 to 74 have dementia, but over the age of 85 about 50% are afflicted with this condition.
Causes of dementia
The reason? There are multiple causes for this condition.
1. Trauma that is accumulative (worst in sports injuries; just look at the history of the former boxer Muhammad Ali who just turned 70) and may mix with medical illnesses like Parkinson’s disease as in this champion boxer. Parkinson’s disease by itself can lead to Parkinson’s disease dementia. Trauma can also cause a subdural hematoma that may be missed in case of milder trauma, but can lead to permanent damage to the brain cells resulting in dementia.
2. Infections like in AIDS dementia, and Creutzfeldt-Jakob Disease can independently cause dementia. There are many other severe infections like tuberculosis, syphilis that can without treatment also lead to dementia in the end stage. Fortunately in our time these diseases are spotted earlier and treated so we no longer see the end stages as in the past.
3. Vascular dementia is another form of dementia and here it is the combination of mini strokes leading to brain substance loss and nutritional deficiency due to circulation problems from severe hardening of the brain arteries. If the brain cells and the supportive glia cells do not get the required oxygen and nutrients they give up their function and we observe the symptoms of dementia.
Even though I described the causes of dementia in the various links to this page as if they would be separate, quite often there can be mixed patterns of dementia where several causes work together in diminishing brain function. This is particularly true in the aging brain.
4. Dementia can also be caused from a lack of vitamin B12. In older age the absorption of vitamin B12 can be a problem because of the lack of the so-called intrinsic factor from the stomach. Read more information about this in the following blog.
Prevention of Dementia
A study that followed aging persons for 4 years and tested cognitive function showed that those who took regular, high enough doses of vitamin D3 were relatively protected from cognitive decline. Unfortunately, 68% of subjects in that study were found to be vitamin D3 deficient. Read the details here.
The other big factor for prevention is regular exercise: http://www.askdrray.com/regular-exercise-will-delay-onset-of-alzheimers-or-dementia/
1. OL Lopez et al. Neurology 2000 Dec 55(12):1863-1869.
2. K Yasojima et al. Brain Res 2000 DEC 887(1):80-89.
3. A Kontush et al. FreeRadicBiol Med2001Jan30(1): 119-128.
4. H Vanderstichele et al. Amyloid 2000Dec7(4):245-258.
5. Neely et al. Lipids 2000 Nov35(11):1249-1257.
6. RA Yokel Neurotoxicology 2000 Oct21(5):813-828.
7. Petanceska et al. Exp Gerontol 2000 Dec 35 (9-10):1317-1325.
8. MB Liddell et al. Brit J Psychiatry 2001 Jan 178: 7-11.
9. Sramek et al.ExpertOpinInvestigDrugs2000Apr9(4):899-915.
10.K Kosaka et al. Neuropathology 2000 March 20(1): 1-7.
11.V Haroutunian et al.Arch Neurol 2000 Aug57(8):1145-1150.
12. C Puckett et al. Am J Hum Genet 1991Aug49(2):320-329.
13. M Haltia Ann Med 2000 Oct 32(7): 439-500.
14. Ferri: Ferri’s Clinical Advisor: Instant Diagnosis and Treatment, 2004 ed., Copyright © 2004 Mosby, Inc.
15. Rakel: Conn’s Current Therapy 2004, 56th ed., Copyright © 2004 Elsevier