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Non-Hodgkin’s Disease

As indicated under “lymphomas” there are several disease entities contained in non-Hodgkin’s disease (also called non-Hodgkin’s lymphoma, NHL), which is common and multifaceted. NHL can be brought on by different causes. For instance, human T-cell leukemia-lymphoma virus(HTLV-1) is endemic in southern Japan, South America, the Caribbean and the southeastern USA and is the cause of an acute illness called the adult T-cell leukemia-lymphoma. This is one of the NHLs and it presents with an aggressive type illness with skin involvement, generalized lymph gland swelling, enlargement of spleen and liver and a leukemia, where the leukemia cells are malignant T lymphocytes.

Non-Hodgkin's Disease

Non-Hodgkin’s Disease

Diffuse large B-cell lymphoma and follicular lymphoma

With most NHL cases the B cells (the antibody producing cells attacking viruses and bacteria) of the immune system are affected with a malignant transformation. In the minority of cases the other branch of the immune system, T cells (killer T cells that get rid of parasites and cancer cells). Common subtypes of NHL are diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma, both of which occur in people in their mid 60’s. 

Here is an overview of many more less common forms of non-Hodgkin’s lymphoma (NHL).


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Last modified: June 5, 2023

This outline is only a teaching aid to patients and should stimulate you to ask the right questions when seeing your doctor. However, the responsibility of treatment stays in the hands of your doctor and you.